Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Sustained release of VEGF from PLGA nanoparticles embedded thermo-sensitive hydrogel in full-thickness porcine bladder acellular matrix | Geng et al. Nanoscale Research Letters 2011 6 312 http content 6 1 312 o Nanoscale Research Letters a SpringerOpen Journal NANO EXPRESS Open Access Sustained release of VEGF from PLGA nanoparticles embedded thermo-sensitive hydrogel in full-thickness porcine bladder acellular matrix Hongquan GengH Hua Song 2 f Jun Qi3 and Daxiang Cui2 Abstract We fabricated a novel vascular endothelial growth factor VEGF -loaded poly lactic-co-glycolic acid PLGA -nanoparticles NPs -embedded thermo-sensitive hydrogel in porcine bladder acellular matrix allograft BAMA system which is designed for achieving a sustained release of VEGF protein and embedding the protein carrier into the BAMA. We identified and optimized various formulations and process parameters to get the preferred particle size entrapment and polydispersibility of the VEGF-NPs and incorporated the VEGF-NPs into the poly ethylene oxide -poly propylene oxide -poly ethylene oxide Pluronic F127 to achieve the preferred VEGF-NPs thermo-sensitive gel system. Then the thermal behavior of the system was proven by in vitro and in vivo study and the kinetic-sustained release profile of the system embedded in porcine bladder acellular matrix was investigated. Results indicated that the bioactivity of the encapsulated VEGF released from the NPs was reserved and the VEGF-NPs thermo-sensitive gel system can achieve sol-gel transmission successfully at appropriate temperature. Furthermore the system can create a satisfactory tissue-compatible environment and an effective VEGF-sustained release approach. In conclusion a novel VEGF-loaded PLGA NPs-embedded thermo-sensitive hydrogel in porcine BAMA system is successfully prepared to provide a promising way for deficient bladder reconstruction therapy. Introduction A variety of congenital and acquired conditions cause compromised bladder capacity and compliance. The major surgical solution is enterocystoplasty whereby the functionally deficient bladder is .
