Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Biomagnetic of Apatite-Coated Cobalt Ferrite: A Core–Shell Particle for Protein Adsorption and pH-Controlled Release | Tang et al. Nanoscale Res Lett 2011 6 19 http content 6 1 19 o Nanoscale Research Letters a SpringerOpen Journal NANO EXPRESS Open Access Biomagnetic of Apatite-Coated Cobalt Ferrite A Core-Shell Particle for Protein Adsorption and pH-Controlled Release I h I I k z t I s k 1 1 3 I I k- . l ri I k m r 2 4 I K S F k . I fs I I k k . k I I I2 4 D r- r- W i I K S I_Ik- r - r A - -f-1 5 I-Ming lang Naieeiip Krishnamra Narauaphol Charoenphandhu Rassmidara Hoonsawat Weeraphat Pon-On 1 Abstract Magnetic nanoparticle composite with a cobalt ferrite CoFe2O4 CF core and an apatite Ap coating was synthesized using a biomineralization process in which a modified simulated body fluid solution is the source of the calcium phosphate for the apatite formation. The core-shell structure formed after the citric acid-stabilized cobalt ferrite CFCA particles were incubated in the SBF solution for 1 week. The mean particle size of CFCA-Ap is about 750 nm. A saturation magnetization of emug-1 and a coercivity of Oe were observed for the CFCA-Ap obtained. Bovine serum albumin BSA was used as the model protein to study the adsorption and release of the proteins by the CFCA-Ap particles. The protein adsorption by the CFCA-Ap particles followed a more typical Freundlich than Langmuir adsorption isotherm. The BSA release as a function of time became less rapid as the CFCA-Ap particles were immersed in higher pH solution thus indicating that the BSA release is dependent on the local pH. Introduction The targeting of biomolecules . drug DNA or protein using delivery vehicles that are biocompatible with the human body is an area of great interest. To combine into one vehicle two types of materials a magnetic material that has the magnetic property needed for the targeting and a biopolymer that possess a biocompatibility with the human body would be of a great advantage to the treatment of human illnesses 1-6 . Magnetic composites can also be .
