Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: IEffect of MWCNTs on Gastric Emptying in Mice | Li et al. Nanoscale Res Lett 2011 6 63 http content 6 1 63 o Nanoscale Research Letters a SpringerOpen Journal NANO EXPRESS Open Access Effect of MWCNTs on Gastric Emptying in Mice Z Li W Qi YX Geng DQ Pan Y Lu JZ Xu WS Wu Abstract After making model of gastric functional disorder FD part of model mice were injected intravenously . with oxide multi-walled carbon nanotubes oMWCNTs to investigate effect of carbon nanotubes on gastric emptying. The results showed that NO content in stomach compared with model group was decreased significantly and close to normal level post-injection with oMWCNTs 500 and 800 pg mouse . In contrast to FD or normal groups the content of acetylcholine Ach in stomach was increased obviously in injection group with 500 or 800 pg mouse of oMWCNTs. The kinetic curve of emptying was fitted to calculate gastric motility factor k the results showed that the k of injection group was much higher than FD and normal. In other words the gastric motility of FD mice was enhanced via injection with oMWCNTs. In certain dosage oMWCNTs could improve gastric emptying and motility. Introduction Carbon nanotubes CNT represent the structural evolution of the archetypal molecular architecture consisting of pure carbon units the C60 fullerene 1 CNT or buckytubes 2 possess extraordinary properties such as high electrical and thermal conductivity great strength and rigidity and being developed for a wealth of applications including field emission 3 energy storage molecular electronics and atomic force microscopy. These properties indicate diverse future biomedical uses in areas such as targeted chemotherapeutics in vitro cell markers diagnostic imaging contrast agents biochemical sensors and photoablative therapy agents 4 . However it was not found in previous works to use carbon nanotubes as single drug to therapy in clinical application no works could prove that the carbon nanotubes can improve biological function of animals and most
