Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The Photodynamic Effect of Different Size ZnO Nanoparticles on Cancer Cell Proliferation In Vitro | Nanoscale Res Lett 2010 5 1063-1071 DOI s11671-010-9603-4 NANO EXPRESS The Photodynamic Effect of Different Size ZnO Nanoparticles on Cancer Cell Proliferation In Vitro Jingyuan Li Dadong Guo Xuemei Wang Huangping Wang Hui Jiang Baoan Chen Received 1 February 2010 Accepted 5 April 2010 Published online 16 April 2010 The Author s 2010. This article is published with open access at Abstract Nanomaterials have widely been used in the field of biological and biomedicine such as tissue imaging diagnosis and cancer therapy. In this study we explored the cytotoxicity and photodynamic effect of different-sized ZnO nanoparticles to target cells. Our observations demonstrated that ZnO nanoparticles exerted dose-dependent and time-dependent cytotoxicity for cancer cells like hepatocellular carcinoma SMMC-7721 cells in vitro. Meanwhile it was observed that UV irradiation could enhance the suppression ability of ZnO nanoparticles on cancer cells proliferation and these effects were in the size-dependent manner. Furthermore when ZnO nanoparticles combined with daunorubicin the related cytotoxicity of anticancer agents on cancer cells was evidently enhanced suggesting that ZnO nanoparticles could play an important role in drug delivery. This may offer the possibility of the great potential and promising applications of the ZnO nanoparticles in clinical and biomedical areas like photodynamic cancer therapy and others. Keywords ZnO nanoparticle SMMC-7721 Photodynamic cancer therapy PDT Size effect Drug delivery Electronic supplementary material The online version of this article doi s11671-010-9603-4 contains supplementary material which is available to authorized users. J. Li D. Guo X. Wang H. Wang H. Jiang State Key Lab of Bioelectronics Chien-Shiung WU Laboratory Southeast University 210096 Nanjing People s Republic of China e-mail xuewang@ B. Chen Department of Hematology Zhongda Hospital Southeast University 210009 Nanjing People s .
