Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Hypertrophy of the feet and ankles presenting in primary hypertrophic osteoarthropathy or pachydermoperiostosis: a case report | Akrout et al. Journal of Medical Case Reports 2012 6 31 http content 6 1 31 JOURNALOF medical case reports CASE REPORT Open Access Hypertrophy of the feet and ankles presenting in primary hypertrophic osteoarthropathy or pachydermoperiostosis a case report Rim Akrout Samar Bendjemaa Héla Fourati Mariem Ezzeddine Imene Hachicha and Soufiene Baklouti Abstract Introduction Pachydermoperiostosis or primary hypertrophic osteoathropathy is a rare genetic disease with autosomal transmission. This disorder which affects both bones and skin is characterized by the association of dermatologic changes pachydermia or thickening of the skin and rheumatologic manifestations periostosis and finger clubbing . Here we report a new observation of pachydermoperiostosis. Case presentation A 20-year-old North African Tunisian Caucasian man presented with hypertrophic osteoarthropathy. On a clinical examination we found morphologic abnormalities of his face and extremities associated with skin changes. The laboratory findings were normal. A work-up disclosed no organic etiology. The final diagnosis consisted of pachydermoperiostosis syndrome. Conclusion Pachydermoperiostosis is a rare entity that should be differentiated from secondary hypertrophic osteoarthropathy and chronic rheumatic diseases. Introduction Hypertrophic osteoarthropathy HOA is a clinical syndrome that causes clubbing of the fingers and toes enlargement of the extremities and pain and swelling of the joints. Patients may have one or more of these manifestations. The syndrome can be primary or secondary. The latter known as hypertrophic pulmonary osteoarthropathy is associated with pulmonary diseases such as lung cancer 1 . Pachydermoperiostosis PDP which is the primary idiopathic form of HOA is characterized by clubbing of the digits of both hands and feet and enlargement of the extremities secondary to periarticular and osseous proliferation. It is a rare genetic disorder with autosomal .