Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Membrane Surface Nanostructures and Adhesion Property of T Lymphocytes Exploited by AFM | Nanoscale Res Lett 2009 4 942-947 DOI s11671-009-9340-8 NANO EXPRESS Membrane Surface Nanostructures and Adhesion Property of T Lymphocytes Exploited by AFM Yangzhe Wu Hongsong Lu Jiye Cai Xianhui He Yi Hu HongXia Zhao Xiaoping Wang Received 29 March 2009 Accepted 5 May 2009 Published online 5 June 2009 to the authors 2009 Abstract The activation of T lymphocytes plays a very important role in T-cell-mediated immune response. Though there are many related literatures the changes of membrane surface nanostructures and adhesion property of T lymphocytes at different activation stages have not been reported yet. However these investigations will help us further understand the biophysical and immunologic function of T lymphocytes in the context of activation. In the present study the membrane architectures of peripheral blood T lymphocytes were obtained by AFM and adhesion force of the cell membrane were measured by acquiring force-distance curves. The results indicated that the cell volume increased with the increases of activation time whereas membrane surface adhesion force decreased even though the local stiffness for resting and activated cells is similar. The results provided complementary and important data to further understand the variation of biophysical Y. Wu J. Cai H Y. Hu Chemistry Department Jinan University Guangzhou 510632 Guangdong People s Republic of China e-mail tjycai@ Y. Wu e-mail jerry_wyzhe@ H. Lu X. He Institution for Tissue Transplantation and Immunology Jinan University Guangzhou 510632 Guangdong People s Republic of China H. Zhao Faculty of Chemical Engineering and Light Industry Guangdong University of Technology Guangzhou 510090 People s Republic of China X. Wang The First Affiliated Hospital Jinan University Guangzhou 510632 Guangdong People s Republic of China properties of T lymphocytes in the context of in vitro activation. Keywords T lymphocytes Cell activation Membrane nanostructures Adhesion force .