Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Leve | Nanoscale Res Lett 2009 4 668-673 DOI S11671-009-9291-0 NANO EXPRESS Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Level Cristina Riggio Gianni Ciofani Vittoria Raffa Alfred Cuschieri Silvestro Micera Received 19 January 2009 Accepted 5 March 2009 Published online 25 March 2009 to the authors 2009 Abstract In this article a carbon nanotube CNT arraybased system combined with a polymer thin film is proposed as an effective drug release device directly at cellular level. The polymeric film embedded in the CNT array is described and characterized in terms of release kinetics while in vitro assays on PC12 cell line have been performed in order to assess the efficiency and functionality of the entrapped agent neural growth factor NGF . PC12 cell differentiation following incubation on the CNT array embedding the alginate delivery film demonstrated the effectiveness of the proposed solution. The achieved results indicate that polymeric technology could be efficiently embedded in CNT array acting as drug delivery system at cellular level. The implication of this study opens several perspectives in particular in the field of neurointerfaces combining several functions into a single platform. Keywords Vertically aligned carbon nanotubes Drug delivery Alginate NGF PC12 cells C. Riggio G. Ciofani V. Raffa A. Cuschieri S. Micera Scuola Superiore Sant Anna Piazza Martiri della Liberta 33 56127 Pisa Italy C. Riggio El CRIM ARTS Lab - Scuola Superiore Sant Anna Viale Rinaldo Piaggio 34 56025 Pontedera PI Italy e-mail criggio@ S. Micera Swiss Federal Institute of Technology ETH Zurich Switzerland Introduction Despite advances in understanding of the mechanisms involved in the evolution of neurodegenerative disorders and neuroactive agents drug delivery to the nervous system remains problematic especially as accessibility to the central nervous system CNS is limited by the .
