Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Assessment of the In Vivo Toxicity of Gold Nanoparticles | Nanoscale Res Lett 2009 4 858-864 DOI S11671-009-9334-6 NANO EXPRESS Assessment of the In Vivo Toxicity of Gold Nanoparticles Yu-Shiun Chen Yao-Ching Hung Ian Liau G. Steve Huang Received 31 March 2009 Accepted 24 April 2009 Published online 8 May 2009 to the authors 2009 Abstract The environmental impact of nanoparticles is evident however their toxicity due to their nanosize is rarely discussed. Gold nanoparticles GNPs may serve as a promising model to address the size-dependent biological response to nanoparticles because they show good biocompatibility and their size can be controlled with great precision during their chemical synthesis. Naked GNPs ranging from 3 to 100 nm were injected intraperitoneally into BALB C mice at a dose of 8 mg kg week. GNPs of 3 5 50 and 100 nm did not show harmful effects however GNPs ranging from 8 to 37 nm induced severe sickness in mice. Mice injected with GNPs in this range showed fatigue loss of appetite change of fur color and weight loss. Starting from day 14 mice in this group exhibited a camellike back and crooked spine. The majority of mice in these groups died within 21 days. Injection of 5 and 3 nm GNPs however did not induce sickness or lethality in mice. Pathological examination of the major organs of the mice in the diseased groups indicated an increase of Kupffer . Chen G. S. Huang H Institute of Nanotechnology National Chiao Tung University Hsinchu Taiwan ROC e-mail gstevehuang@ . Chen Department of Material Science and Engineering National Chiao Tung University Hsinchu Taiwan ROC . Hung Section of Gynecologic Oncology Department of Obstetrics and Gynecology China Medical University and Hospital 91 Hsueh Shih Rd. Taichung 404 Taiwan ROC I. Liau Department of Applied Chemistry National Chiao Tung University Hsinchu Taiwan ROC cells in the liver loss of structural integrity in the lungs and diffusion of white pulp in the spleen. The pathological abnormality was associated with the
