Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Folate Functionalized Boron Nitride Nanotubes and their Selective Uptake by Glioblastoma Multiforme Cells: Implications for their Use as Boron Carriers in Clinical Boron Neutron Capture Therapy | Nanoscale Res Lett 2009 4 113-121 DOI s11671-008-9210-9 NANO EXPRESS Folate Functionalized Boron Nitride Nanotubes and their Selective Uptake by Glioblastoma Multiforme Cells Implications for their Use as Boron Carriers in Clinical Boron Neutron Capture Therapy Gianni Ciofani Vittoria Raffa Arianna Menciassi Alfred Cuschieri Received 17 October 2008 Accepted 11 November 2008 Published online 25 November 2008 to the authors 2008 Abstract Boron neutron capture therapy BNCT is increasingly being used in the treatment of several aggressive cancers including cerebral glioblastoma multiforme. The main requirement for this therapy is selective targeting of tumor cells by sufficient quantities of 10B atoms required for their capture irradiation with low-energy thermal neutrons. The low content of boron targeting species in glioblastoma multiforme accounts for the difficulty in selective targeting of this very malignant cerebral tumor by this radiation modality. In the present study we have used for the first time boron nitride nanotubes as carriers of boron atoms to overcome this problem and enhance the selective targeting and ablative efficacy of BNCT for these tumors. Following their dispersion in aqueous solution by noncovalent coating with biocompatible poly-L-lysine solutions boron nitride nanotubes were functionalized with a fluorescent probe quantum dots to enable their tracking and with folic acid as selective tumor targeting ligand. Initial in vitro studies have confirmed substantive and selective uptake of these nanovectors by glioblastoma multiforme cells an observation which confirms their potential clinical application for BNCT therapy for these malignant cerebral tumors. G. Ciofani V. Raffa A. Menciassi A. Cuschieri Scuola Superiore Sant Anna Piazza Martiri della Liberta 33 56127 Pisa Italy G. Ciofani H Scuola Superiore Sant Anna CRIM Lab - Center for Applied Research in Micro and Nano Engineering Viale Rinaldo Piaggio 34 56025 Pontedera Pisa Italy .
