Tham khảo tài liệu 'amyotrophic lateral sclerosis part 4', khoa học tự nhiên, công nghệ sinh học phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | 102 Amyotrophic Lateral Sclerosis euthanasia is delayed 3 years. These findings suggest that this disease afflicting dogs is closely related to ALS and identify canine degenerative myelopathy to be the first recognized spontaneously occurring animal model for ALS. The canine ALS model may be particularly valuable for evaluating therapeutic interventions as the environmental conditions and the SOD1 level of expression mimic better the human ALS situation. Pig Pigs although not easily kept for laboratory research are readily available for biomedical research through the large-scale industrial production of pigs produced for human consumption. Recent research has facilitated the biological experimentation with pigs and helped develop the pig into a novel model organism for biomedical research. The domesticated pig Sus scrofa shares several similarities with human in particular the size of organs and various aspects of anatomy and physiology. The development of somatic cloning technology and the merger with techniques of targeted genetic modification and conditional gene expression will enhance the possibilities for creating useful models for human diseases in pigs. The pig has also evolved as the major target species for producing xenografts in order to provide appropriate human organs. The sequencing of the domestic pig genome has not yet been fully completed. However initial draft revealed that the size and composition of the porcine genome is comparable to that of humans comprising about billion base pairs Hart et al. 2007 . Furthermore both gene content and sequence are highly conserved between pig and human. Detailed information on the porcine genome together with emerging transgenic technologies such as siRNA or conditional knockouts will enhance our possibilities to create useful pig models. Other advantages of using domestic pigs to model human diseases include high fertility great abundance rapid growth anatomy and physiology not too different from
