Tham khảo tài liệu 'insecticides basic and other applications part 12', khoa học tự nhiên, công nghệ sinh học phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Ameliorative Effect of Vitamin E on Sensorimotor and Cognitive Changes Induced by Chronic Chlorpyrifos Exposure in Wistar Rats 209 death Kehrer 1993 Sally et al. 2003 . The body is however endowed with cellular defence systems to combat the menace posed by the oxidants to the body. These defensive systems are accomplished by the activities of both the enzymatic and non-enzymatic antioxidants which mitigate the toxic effect of oxidants. However under increased ROS production the antioxidant cellular defensive systems are overwhelmed resulting in oxidative stress. Under this type of condition exogenous supplementation of antioxidants becomes imperative to minimise tissue damage. Vitamin E is nature s major lipid soluble chain breaking antioxidant that protects biological membranes and lipoproteins from oxidative stress Osfor et al. 2010 . The main biological function of vitamin E is its direct influence on cellular responses to oxidative stress through modulation of signal transduction pathway Hsu Guo 2002 . Vitamin E primarily scavenges peroxyl radicals and is a major inhibitor of the free radical chain reaction of lipid peroxidation Maxwell 1995 Halliwell Gutteridge 1999 . We have earlier demonstrated the mitigating effect of vitamin E on short-term neurobehavioural changes induced by acute CPF exposure Ambali Aliyu 2012 . The present study was therefore aimed at evaluating the ameliorative effect of vitamin E on sensorimotor and cognitive changes induced by chronic CPF exposure in Wistar rats. 2. Materials and methods Experimental animals and housing Twenty 10 week old male Wistar rats 104 used for this study were obtained from the Laboratory Animal House of the Department of Veterinary Physiology and Pharmacology Ahmadu Bello University Zaria Nigeria. The animals were housed in plastic cages and allowed to acclimatize for at least two weeks in the laboratory prior to the commencement of the experiment. They were fed on standard rat pellets and water was .
