Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: In Vitro Structural and Functional Evaluation of Gold Nanoparticles Conjugated Antibiotics | Nanoscale Res Lett 2007 2 614-622 DOI S11671-007-9104-2 NANO EXPRESS In Vitro Structural and Functional Evaluation of Gold Nanoparticles Conjugated Antibiotics Biswarup Saha Jaydeep Bhattacharya Ananda Mukherjee Anup Kumar Ghosh Chitta Ranjan Santra Anjan K. Dasgupta Parimal Karmakar Received 26 June 2007 Accepted 30 October 2007 Published online 17 November 2007 to the authors 2007 Abstract Bactericidal efficacy of gold nanoparticles conjugated with ampicillin streptomycin and kanamycin were evaluated. Gold nanoparticles Gnps were conjugated with the antibiotics during the synthesis of nanoparticles utilizing the combined reducing property of antibiotics and sodium borohydride. The conjugation of nanoparticles was confirmed by dynamic light scattering DLS and electron microscopic EM studies. Such Gnps conjugated antibiotics showed greater bactericidal activity in standard agar well diffusion assay. The minimal inhibitory concentration MIC values of all the three antibiotics along with their Gnps conjugated forms were determined in three bacterial strains Escherichia coll DH5a Micrococcus luteus and Staphylococcus aureus. Among them streptomycin and kanamycin showed significant reduction Biswarup Saha and Jaydeep Bhattacharya authors contributed equally. B. Saha A. Mukherjee P. Karmakar Department of Life Science and Biotechnology Jadavpur University Kolkata 700 032 WB India J. Bhattacharya Department of Microbiology Vijoygarh Jyotish Roy College University of Calcutta Jadavpur Kolkata 700 032 WB India A. K. Ghosh Department of Instrumentation Science Jadavpur University Kolkata 700 032 WB India C. R. Santra Department of Chemistry Netaji Nagar Day College NSC Bose Road Regent Estate Kolkata 700 092 WB India A. K. Dasgupta Department of Biochemistry University of Calcutta 35 Ballygunge Circular Road Kolkata 700 019 WB India in MIC values in their Gnps conjugated form whereas Gnps conjugated ampicillin showed slight decrement in the MIC value compared to its
