Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Decreased Fibroblast and Increased Osteoblast Functions on Ionic Plasma Deposited Nanostructured Ti Coatings | Nanoscale Res Lett 2007 2 385-390 DOI S11671-007-9069-1 NANO EXPRESS Decreased Fibroblast and Increased Osteoblast Functions on Ionic Plasma Deposited Nanostructured Ti Coatings Ariel Cohen Peishan Liu-Synder Dan Storey Thomas J. Webster Received 2 May 2007 Accepted 6 June 2007 Published online 4 July 2007 to the authors 2007 Abstract Bioactive coatings are in high demand to control cellular functions for numerous medical devices. The objective of this in vitro study was to characterize for the first time fibroblast fibrous scar tissue forming cells adhesion and proliferation on an important polymeric biomaterial silicone coated with titanium using a novel ionic plasma deposition IPD process. Fibroblasts are one of the first anchorage-dependent cells to arrive at an implant surface during the wound healing process. Persistent excessive functions of fibroblasts have been linked to detrimental fibrous tissue formation which may cause implant failure. The IPD process creates a surface-engineered nanostructure with features usually below 100 nm by first using a vacuum to remove all contaminants then guiding charged metallic ions or plasma to the surface of a medical device at ambient temperature. Results demonstrated that compared to currently used titanium and uncoated silicone silicone coated with titanium using IPD significantly decreased fibroblast adhesion and proliferation. Results also showed competitively increased osteoblast bone-forming cells over fibroblast adhesion on silicone coated with titanium in contrast osteoblast adhesion was not competitively increased over fibroblast adhesion on uncoated silicone or titanium controls. In this manner this study strongly suggests that IPD should be further studied for biomaterial applications in which fibrous tissue encapsulation is undesirable such as for orthopedic implants cardiovascular components etc. . A. Cohen P. Liu-Synder T. J. Webster El Divisions of Engineering and Orthopaedics Brown University 184
