Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: MASSP3: A System for Predicting Protein Secondary Structure | Hindawi Publishing Corporation EURASIP Journal on Applied Signal Processing Volume 2006 Article ID 17195 Pages 1-9 DOI ASP 2006 17195 MASSP3 A System for Predicting Protein Secondary Structure Giuliano Armano Alessandro Orro and Eloisa Vargiu Department of Electrical and Electronic Engineering University of Cagliari Piazza d Armi 09123 Cagliari Italy Received 15 May 2005 Revised 22 September 2005 Accepted 1 December 2005 A system that resorts to multiple experts for dealing with the problem of predicting secondary structures is described whose performances are comparable to those obtained by other state-of-the-art predictors. The system performs an overall processing based on two main steps first a sequence-to-structure prediction is performed by resorting to a population of hybrid genetic-neural experts and then a structure-to-structure prediction is performed by resorting to a feedforward artificial neural networks. To investigate the performance of the proposed approach the system has been tested on the RS126 set of proteins. Experimental results about 76 of accuracy point to the validity of the approach. Copyright 2006 Hindawi Publishing Corporation. All rights reserved. 1. INTRODUCTION Due to the strict relation between protein function and structure the prediction of protein 3D structure has during recent years become one of the most important tasks in bioinformatics. In fact notwithstanding the increase of experimental data on protein structures available in public databases the gap between known sequences 165 000 entries in Swiss-Prot 1 in December 2004 and known tertiary structures 28 000 entries in PDB 2 in December 2004 is constantly increasing. The need for automatic methods has brought the development of several prediction and modeling tools but despite the increase of accuracy a general methodology to solve the problem has not been yet devised. Building complete protein tertiary structure is still not a tractable task and most methodologies .
