Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Automatic Characterization of Myocardial Perfusion in Contrast Enhanced MRI | EURASIP Journal on Applied Signal Processing 2003 5 413-421 2003 Hindawi Publishing Corporation Automatic Characterization of Myocardial Perfusion in Contrast Enhanced MRI Vincenzo Positano Institute of Clinical Physiology National Research Council Via Moruzzi 1 LocSan Cataldo 56100 Pisa Italy Email positano@. it Maria Filomena Santarelli Institute of Clinical Physiology National Research Council Via Moruzzi 1 LocSan Cataldo 56100 Pisa Italy Email santarel@ Luigi Landini Department of Information Engineering University of Pisa Via Diotisalvi 2 56122 Pisa Italy Email llandini@ Received 29 January 2002 and in revised form 16 October 2002 The use of contrast medium in cardiac MRI allows joining the high-resolution anatomical information provided by standard magnetic resonance with functional information obtained by means of the perfusion of contrast agent in myocardial tissues. The current approach to perfusion MRI characterization is the qualitative one based on visual inspection of images. Moving to quantitative analysis requires extraction of numerical indices of myocardium perfusion by analysis oftime intensity curves related to the area of interest. The main problem in quantitative image sequence analysis is the heart movement mainly due to patient respiration. We propose an automatic procedure based on image registration segmentation of the myocardium and extraction and analysis of time intensity curves. The procedure requires a minimal user interaction is robust with respect to the user input and allows effective characterization of myocardial perfusion. The algorithm was tested on cardiac MR images acquired from voluntaries and in clinical routine. Keywords and phrases magnetic resonance imaging image registration contrast-enhanced MRI myocardial perfusion mutual information. 1. INTRODUCTION The use of contrast medium CM to enhance the information provided by magnetic resonance is a growing technique. In fact the use of .
