Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Microarray BASICA: Background Adjustment, Segmentation, Image Compression and Analysis of Microarray Images | EURASIP Journal on Applied Signal Processing 2004 1 92-107 2004 Hindawi Publishing Corporation Microarray BASICA Background Adjustment Segmentation Image Compression and Analysis of Microarray Images Jianping Hua Department of Electrical Engineering Texas A M University College Station TX 77843 USA Email huajp@ Zhongmin Liu Advanced Digital Imaging Research 2450 South Shore Boulevard Suite 305 League City TX 77573 USA Email liuzm@ Zixiang Xiong Department of Electrical Engineering Texas A M University College Station TX 77843 USA Email zx@ Qiang Wu Advanced Digital Imaging Research 2450 South Shore Boulevard Suite 305 League City TX 77573 USA Email qwu@ Kenneth R. Castleman Advanced Digital Imaging Research 2450 South Shore Boulevard Suite 305 League City TX 77573 USA Email castleman@ Received 14 March 2003 Revised 23 September 2003 This paper presents microarray BASICA an integrated image processing tool for background adjustment segmentation image compression and analysis of cDNA microarray images. BASICA uses a fast Mann-Whitney test-based algorithm to segment cDNA microarray images and performs postprocessing to eliminate the segmentation irregularities. The segmentation results along with the foreground and background intensities obtained with the background adjustment are then used for independent compression of the foreground and background. We introduce a new distortion measurement for cDNA microarray image compression and devise a coding scheme by modifying the embedded block coding with optimized truncation EBCOT algorithm Taubman 2000 to achieve optimal rate-distortion performance in lossy coding while still maintaining outstanding lossless compression performance. Experimental results show that the bit rate required to ensure sufficiently accurate gene expression measurement varies and depends on the quality of cDNA microarray images. For homogeneously hybridized cDNA microarray images BASICA is able
