There is a need for development of new diagnostic tools to allow earlier detection of active disease, predict disease progression and evaluate the response to periodontal therapy, thereby improving the clinical management of patients with periodontal diseases. Advances in periodontal diseases diagnostic research are moving toward methods whereby periodontal risk can be identified and quantified by objective measures such as biomarkers. Gingival crevicular fluid (GCF) and salivary levels of several growth factors, cytokines and enzymes of host origin appear to hold the greatest promise as valuable biomarkers in assessing development of periodontal disease (Buduneli & Kinane, 2011; Giannobile et al., 2003; Gurkan et al., 2008; Goncalves et al., 2009;. | Clive Oxenden Christina Latham-Koenig Paul Seligson 100 NEW Elementary Student s Book New ENGLISH FILE Clive Oxenden Christina Latham-Koenig Paul Seligson New ENGLISH FILE Elementary Student s Book Paul Scligson and Clive Oxcnden arc the original co-authors of English File I pub. 1996 and English File 2 pub. 1997 . OXFORD UNIVERSITY PRESS Contents Grammar Vocabulary Pronunciation 4 Nice to meet you verb be pronouns you etc. numbers 1 -20 days of the week vowel sounds word stress 6 I m not English I m Scottish verb be and countries and nationalities numbers 20-1 000 vowel sounds 8 13 His name her name possessive adjectives my your etc. personal information the alphabet 3 and au 10 n Turn off your mobiles a an plurals this that these those the classroom common objects classroom language vowel sounds 12 13 14 Practical English On a plane Writing Completing a form Revise Check What do you remember What can you do 16 Cappuccino and chips present simple and verb phrases irregular plurals consonant sounds third person 18 When Natasha meets Darren. present simple common verb phrases consonant sounds 20 Q An artist and a musician a an jobs jobs consonant sounds 22 Relatively famous possessive s family consonant sounds 24 Practical English At a hotel 25 Writing An informal e-mail letter 26 Revise Check What do you remember What can you do 28 c Pretty woman adjertives adjectives quite very vowel sounds 30 D Wake up get out of bed. telling the time present simple daily routine the letter 0 32 The island with a secret adverbs of frequency time words and expressions the letter h 34 On the last Wednesday in prepositions of time the date word stress Ô and 0 August 36 Practical English In a coffee shop 37 Writing A magazine article 38 Revise Check What do you remember What can you do 40 1 can t dance can can t verb phrases sentence stress 42 Shopping - men love it like verb -ing free time activities g sentence stress 44 Fatal attraction objert pronouns me. you him etc. love .
