Upper respiratory tract infections and, especially, sinusitis are frequently encountered in the day-to-day practice of infectious disease specialists, allergists, pediatricians, otolaryngologists, internists, and family practitioners. The range of causative agents and available therapies and the constantly changing spectrum of antibiotic resistance can make it difficult to select the most appropriate course of treatment. Given the increasing global concerns regarding the scale of worldwide bacterial resistance, which is largely because of the misuse and overuse of antibiotics, information that can enable physicians to optimize management of infections such as sinusitis will be of great value
