I can safely state that no one truly comprehends the physiology and pathophysiology of the microvasculature. In a large measure, this less than desirable state is the result of an explosion of new scientific data that creates paradoxically [or maybe poetically] a concomitant explosion of ignorance. But challenges enhance curiosity. Regardless how far scientists’ understanding may be from the natural laws that regulate microvessel functions, we share an incumbency to accumulate and disseminate, by whatever means, current new concepts based upon the latest tested investigations. .