The next important milestone emerged in 1990 when three independent working groups described the role of 2-glycoprotein I as a target antigen in antiphospholipid antibodies’ action (Galli M, et al; 1990, Matsura E, et al; 1990, McNeil HP, et al; 1990). This discovery substantially changed point of view of many of the researchers and also clinical practisers in the topic and it led to research of 2-glycoprotein I structure, function and confirmation of significance of its antibodies presence during the next years
