Epidemiological studies conducted during the past decade revealed that CD is one of the most common lifelong disorders worldwide. CD can manifest with a previously unsuspected range of clinical presentations, including the typical malabsorption syndrome and a spectrum of symptoms potentially affecting any organ system. Since CD is often atypical or even silent on clinical ground, many cases remain undiagnosed and exposed to the risk of long term complications, such as anemia and other hematological complications, osteoporosis, neurological complications or cancer
