In recent years, there have been noticeable shifts in the age of onset of symptoms and in the clinical presentation of CD, changes that seem to be associated with a delayed introduction of gluten coupled with its reduced amount in the complications in the diet. Another controversial topic concerns the complications of untreated CD. Multiple studies that have focused on the biochemistry and toxicity of gluten‐containing grains and the immune response to these grains suggest that individuals affected by CD should be treated, irrespective of the presence or absence of symptoms and/or associated conditions
