Such an integrative approach in basic and clinical gastroenterology seems to be essential for the pathomechanism, proper diagnosis and management of patients who suffer from gastrointestinal disorders. The potential reader will not only find in this book the recent advances in the physiology and pathomechanism of GI tract disorders, but also the treatment options based on pharmacological and surgical intervention and the recent advances in the biological therapy with probiotics and prebiotics, which nowadays is a rapidly growing area of interest. For instance, Betta and Vitaliti described in their review, the direct and indirect effects of probiotics in the functional interactions between bacteria, gut epithelium, gut mucosal immune system.