The chapter provides insight into the early assessment process and the application of precaution, an often poorly described management action rarely captured in peer review literature. The situation surrounding this potential new threat to blood safety was largely resolved in mid-2011 when it was determined that the virus was an artifact from contaminated patient samples and from contamination stemming from a diagnostic test kit widely used by researchers. The case study provides good assessment and management insight into the application of early precautionary action and the use of expert opinion for proactive risk management of emerging blood-borne pathogens