In this chapter I will review the current status of treatment for schizophrenia in terms of effectiveness and safety, and discuss what treatment advances have been made in the last century, and how treatment interventions might and should develop as the 21st century unfolds. The emphasis of the chapter will be on pharmacological treatment and the scope for new drugs, but I will also discuss briefly the place of community systems of care, the role of inpatient services, rehabilitation and recovery models, and to a much lesser degree I will also discuss the developing role of psycho-social interventions