Although in many trials haloperidol has been used as the standard comparator, the clinical trial evidence for haloperidol itself is much less impressive than one might expect (Barry et al 2012). By their very nature systematic reviews and RCTs provide only average indices of probable efficacy in groups of individuals recruited to the study in question. Although many RCTs attempt to limit inclusion criteria to a single category of diagnosis from DSM4 or ICD10, many studies include individuals with different types of schizophrenic diagnosis such as schizoaffective disorder. In all RCTs, even those recruiting according to DSM-4 or ICD10 diagnoses,.
