Clearly a more stratified approach to clinical trials would help identify those subgroups who appear to be the best responders to a particular intervention. To date however there is little to suggest that stratification on the basis of clinical characteristics successfully helps predict which drugs work best for which patients. There is a pressing need for the development of biomarkers with clinical utility, for mental health problems. Such measures could help stratify clinical populations or provide better markers of efficacy in clinical trials, and would complement the current use of clinical outcome scales. Clinicians are also well aware that many.
