Consequences of agitation include self-extubation, removal of IV catheters, dyssynchrony with mechanical ventilation, and, perhaps, a long-term risk of psychiatric problems, such as delirium and posttraumatic stress disorder can be prevented by a proper sedation. Prolonged and excessive sedation are problematic too, interfering with weaning from mechanical ventilation and leading to increased rates of nosocomial pneumonia, prolonged ICU stays, and difficulty identifying new problems, such as myocardial infarction or stroke
