The advantages and limitations of conventional structural MRI for the diagnosis and monitoring of MS are discussed by Andreadou (Chapter 15). There is often a disparity between the level of structural abnormality seen on MRI and level of cognitive difficulties expressed by the patient with MS. Clinical interview and neuropsychological assessment are vitally impairment, not only from an initial diagnostic perspective but also in terms of longer term planning and care. Mike, Guttman and Illes (Chapter 16) consider cognitive impairment in MS and its relationship to grey matter findings with MRI. Although significant correlations between quantified measures of grey matter integrity and level of cognitive impairment are observed, this.
