Huang, Yen and Lu (Chapter 18) review the role of SPECT in the diagnosis of idiopathic Parkinson’s disease and its differentiation from other conditions characterised by parkinsonisms such as dementia with Lewy Bodies (DLB) and vascular parkinsonism. Accurate diagnosis is clearly critical for treatment and prognosis, and the authors provide a very useful overview of recent developments in dopamine transporter imaging which have led to important advances in this area. Fragile X-associated tremor/Ataxia syndrome (FXTAS), formally identified in 2001, is a late-onset neurodegenerative condition occurring in carriers of a fragile X gene (FMR1) premutation. Rodriguez-Revenga et al
