This volume is the first book-length survey of caveolae and lipid rafts. Interest has developed rapidly in the role of these surface microdomains in such diverse fields as transmembrane signaling, cell locomotion, vascular relaxation, senescence, and the uptake and exit from cells of viruses and bacteria. Individual chapters in this volume cover areas as diverse as the forces that induce and maintain membrane invaginations, and the clinical relevance of multiprotein complexes at the cell surface, defects in which are associated with cancer, and Alzheimer’s and prion-dependent diseases