It has been stated that our knowledge doubles every 20 years, but that may be an understatement when considering the Life Sciences. A series of discoveries and inventions have propelled our knowledge from the recognition that DNA is the genetic material to a basic molecular understanding of ourselves and the living world around us in less than 50 years. Crucial to this rapid progress was the discovery of the double-helical structure of DNA, which laid the foundation for all hybridization based technologies.