The third chapter in this section is dedicated to bone mineral density (BMD) changes in patients with SpA. BMD has been investigated mainly in patients with AS. The authors investigated BMD changes in AS and in other diseases belonging to the SpA group – ReA (Reactive Arthritis), PsA (Psoriatic Arthritis), EnA (Entheropathic Arthritis) - to assess the relationship between changes in BMD and specific disease- related variables like duration, physical disability and immobility, activity of the disease, and medications. The results were also compared with a group of patients with Rheumatoid Arthritis (RA) and healthy people. Several conclusions were obtained but.