It may also infiltrate different organs, including liver, spleen, lymph nodes, CNS, kidneys, and gonads. Treatment options for patients with acute leukemia include chemotherapy, radiation therapy, targeted therapy, immunotherapy and stem cell or bone marrow transplantation. Finding a cure is a realistic goal for both ALL and AML, especially in younger patients. However, long-term survival is reachable in about one half of patients with acute lymphoblastic leukemia and in the minority of patients with acute myeloid leukemia. Current research, such as new genes whose protein products are suitable for targeted therapy and new strategies of immunotherapy, is focalized to improve therapy for this challenging disease