Presti et al. took two extra biopsies laterally on each side at the base and mid gland in addition to the traditional sextant technique in an effort to include more peripheral zone tissue in their sampling (Presti et al., 2000). This produced a 10-core biopsy. They enrolled 483 men with either abnormal DRE or a PSA 4 ng/mL. On analysis of the cancer detection rate from each side, it was discovered that the traditional sextant technique missed 20% of cancers. Eight cancers were missed by the 10-biopsy scheme and were detected by lesiondirected or transition zone biopsies instead, for a detection rate of 96%. By eliminating.
