Studies were also carried out on digitally-reconstructed radical prostatectomy specimens which showed the inadequacy of the traditional sextant biopsy method. In one study by Chen et al., simulation biopsy strategies were conducted on whole-mount radical prostatectomy specimens from 180 patients and it was found that only 73% of cancers were detected by sextant biopsy (Chen et al., 1997). Using a 10-core biopsy scheme, incorporating the midline peripheral zone, the inferior portion of the anterior horn of the peripheral zone, and the transition zone, they picked up 96% of cancers with a volume (clinically significant). Bauer et al. studied 201 step-sectioned whole mount radical prostatectomy specimens and mapped out.
