The data from this large study provide a strong argument against the use of an arbitrary PSA threshold to select men for prostate biopsy. The aim of prostate biopsy is not to detect each and every prostate cancer. After all, the Prostate Cancer Prevention Trial demonstrates that the majority of prostate cancers are in men with a normal PSA level. The aim of prostate biopsy is actually to detect those prostate cancers with the potential for causing harm. It has been estimated that, of asymptomatic men in whom prostate cancer is detected by prostate biopsy following PSA measurement, around 50% (Draisma, 2003) do not require active treatment. Men.
