Observational studies, and theoretical considerations, suggest that rebiopsy will detect prostate cancer in some men with an initially negative prostate biopsy. These studies reported multivariate analyses of predictive factors for positive repeat biopsy but there was disagreement on which factors predict re-biopsy outcome. There is evidence, however, that the odds of high grade prostate cancer are reduced if a man has previously had a negative biopsy.(Djavan, 2000; Eggener, 2005; López-Corona, 2003; Mian, 2002; Roobal, 2006) Using the results from the European Prostate Cancer Detection Study, there were no significant differences found in the tumor characteristics of stage and Gleason score comparing the first and second biopsy
