All men older than 40 years and attended at HOSCAR or DIPRECA, without a previous history of prostate cancer and fulfilled the criteria’s for prostate cancer screening or a prostate biopsy were invited to participate. Biopsy criteria were; serum PSA ≥ and /or digital rectal examination (DRE) abnormal. Exclusion criteria were older than 85 years and a life expectancy of less than 5 years. There were 2 groups of men; firstly men attending outpatients, where routine prostate cancer screening was carried out, in addition to the normal PSA test, the men were offered CPC diagnostic testing