Costs of pre-biopsy tests, biopsy costs (including biopsy kit, ultrasound time, procedure cost, pathology cost, drug cost, hospital bed cost) were obtained from the Hospital Costs Unit Hospital de Carabineros de Chile and Hospital DIPRECA and based on Public Health Service (PHS) list prices in the case of Public Health Patients (FONASA) and Private Health Insurance (PHI) list prices in the case of Private Patients (Isapres). Costs for CPC detection were obtained from the Instituto de Bio-Oncology Costs Unit. Costs for complications of the biopsy were based on local estimates derived from the Hospital Statistical Unit (Vallejos, 2003). Patients with fever, defined as 38°C were hospitalized and treated.