More recently the results of the Prostate Cancer Prevention Trial (PCPT) (Thompson et al. 2003) demonstrated that there is no PSA threshold below which one can confidently exclude a diagnosis of prostate cancer. The PCPT trial protocol required “normal” men with very low levels of PSA to be biopsied at the end of the trial and it was observed that of men with a PSA ng/mL, of men with a PSA ng/mL, and of men with a PSA