Although rare, cytology of signet ring cell melanoma has been on record. Tsang et al. (1993) documented a case that manifested as a groin mass in a patient who had undergone below knee amputation for superficial spreading melanoma of the right foot. FNA smears in this case showed poorly cohesive, large cells with eccentric nuclei, most of which exhibited signet ring morphology. Only a small proportion of cells displayed melanin pigment clinching the right diagnosis. In the absence of melanin pigment and the clinical history, such cases are likely to be misdiagnosed as metastatic signet ring cell adenocarcinoma. Appropriate history and application of ICC can avoid misinterpretation of.
