The objective of this current chapter is to review the techniques whose potential to noninvasively determine Breslow index has been studied. Basic and technical principles of each technique will be mentioned as well as their accuracy in the determination of a factor whose importance in the clinical management of melanoma is so important as previously demonstrated. Currently Breslow index is measured by the anatomo-pathologist after incisional or excisional biopsy of the suspected lesion. So why non invasive determination of Breslow index would be of utmost clinical value?.
