To our knowledge, the only study on Breslow index determination using DRS was carried out on phantoms as a preliminary study prior to a clinical trial. Two-layer phantoms mimicking dermis ( mm thick) for the bottom layer and melanoma (2, 3, 4, 5 and 6 mm) for the upper layer were made of gelatine as a solid 3D-matrix, intralipids for the scattering properties and coffee for the absorbing properties of melanoma. Based on the slopes of decreasing intensities recorded at the 5 different inter-fibre distances (271, 536, 834, 1076 and 1341 μm), the five different top layers’ thicknesses could be discriminated. Further works need to discriminate thicknesses.
