To our knowledge, no study has yet addressed the issue of Breslow index determination using OCT. Only one study tried to determine OCT specific features of benign and malignant melanocytic skin lesions. OCT of benign nevi demonstrated correlates of typical histological features including the finger-shaped elongation of rete ridges and dense cell clusters in the dermoepidermal junction zone and/or dermis. OCT features of malignant melanoma were large vertically arranged icicle-shaped structures, which mainly corresponded to dense dermal infiltrates of melanocytes as confirmed by histology. However Gambichler (Gambichler, Regeniter et al. 2007) were not able to detect any definitive features in OCT images enabling to differentiate tumour subtypes and.