They found that AAV5 and 7-syn-GFP resulted in the highest percentage of nigral dopaminergic neurons transduction, where AAV7 showed the highest efficiency in transducing the nigrostriatal projection pathway. Accordingly, they conclude that AAV7-syn-GFP is the most suitable SN gene delivery vehicle in mice. In the eleventh chapter, Okada et al. developed a new method of producing AAV vectors. They applied these AAV vectors in muscle transduction for the treatment of Duchenne muscular dystrophy (DMD). In chapter twelve, Sunico et al. introduce their study on the function of 2 dysregulated proteins in pathological events occurring at the peripheral (nerve) and central (motoneuron) levels after the severe crushing of a.
