More recently, a QSAR (Quantitative Structure Activity Relantionship) investigation was carried out on a series of nostoclide analogues presenting the general structure (43) to correlate molecular descriptions with their in vitro biological activity (the ability to interfere with ligh-driven reduction of ferrycianide by isolated spinach chloroplasts thylakoid membranes). The results of this investigation suggested that the degree of inhibition efficiency of this class of compounds is intimately associated with their polarity (Teixeira et al, 2009). Thus, it is likely that new nostoclide analogues with higher polarity could display improved biological activity. At the moment that this book chapter is written, there is no report on the literature concerning.
