A descriptive cross section study was done including 132 laborers of the tomato crop in the location of la Merced – Caldas, during 2009 and 2010. This study considered three phases: the first was the diagnosis to determine the biomarkers for the chosen pesticides. An analysis was made on pesticides residues in tomatoes as well as the characterization of the present productive systems of the crop through a participating rural diagnosis. The second phase was intervention to guide the demonstration plots implementation wherein the good agricultural practices (GAPs) were shown which were compared to other plots managed under a traditional production system. The process of intervention was.