The determination of enzyme AChE continues to be widely used to measure the exposure to OF and C, however, interpretations of results are highly variable, since there are genetic and physiological causes as well as associated pathologies, which can decrease the levels of this enzyme (Varona et al, 2007). In addition, there is a significant variation within the same individual, therefore, the medical surveillance of laborers continuously exposed to these two groups of pesticides must also include not only the medical examination, but also the determination of enzyme AChE preexposure ( baseline) and quarterly for the duration of the exposure (Varona et al, 2007)