Previous World Health Organization studies have examined the aggregate disease burden attributed to key environmental risks globally and regionally, quantifying the amount of death and disease caused by factors such as unsafe drinking-water and sanitation, and indoor and outdoor air pollution. Building from that experience, this present study examines how specific diseases and injuries are impacted by environmental risks, and which regions and populations are most vulnerable to environmentally-mediated diseases and injuries. This report confirms that approximately one-quarter of the global disease burden, and more than one-third of the burden among children, is due to modifiable environmental factors. The analysis here also goes a step further, and systematically analyzes how different diseases.